时间：2022年6月1日（周三）14:00-15:00 

Time：2:00-3:00 PM, Wednesday, June 1st, 2022

Zoom ID：835 4055 6736

主持人：西湖大学生命科学学院讲席教授 于洪涛

Host: Prof. Hongtao Yu, Chair Professor, School of Life Sciences

主讲人/Speaker：

Prof. Dieter Wolf

Group Leader, Department of Medicine II Technical University Munich

Visiting Professor, School of Pharmaceutical Sciences, Xiamen University, China

Dr. Wolf obtained his M.D. from the Ludwig-Maximilians-University in Munich, Germany. Upon postdoctoral work at the Helmholtz Centre Munich, the Department of Cell Biology at Harvard Medical School, and the Department of Pathology at Stanford University School of Medicine, he became an Assistant Professor at Harvard University, School of Public Health in 1998, advancing to Associate Professor in 2003. In 2007, he moved to the Burnham Institute in La Jolla as Full Professor. Since 2015, Dr. Wolf has been holding a part-time appointment as a Distinguished Professor at Xiamen University. In 2019, he joined the MGZ Medical Genetics Center in Munich as a resident in clinical genetics and Medical Head of the Biomarker Program and became a part-time Group Leader at the Department of Medicine II of the Technical University Munich in September 2021.

报告题目/Title:

Mechanism of Protein Homeostasis and Energy Metabolism in Cancer

讲座摘要/Abstract:

Research in Dr. Wolf’s laboratory focusses on energy and protein metabolism as mutually intertwined processes critical for the generation of biomass from nutrients – and thus the growth and proliferation of cancer cells. The work has concentrated on conserved pathways regulating protein homeostasis and associated stress response pathways. 

eIF3 is a 13-subunit protein complex with essential functions in mRNA translation, including translation initiation, elongation, and termination but the basis of this multifunctionality remains unknown. Recent efforts in the lab have focused on deciphering the role of distinct functional modules of eIF3 in mRNA selectivity and cancer. We discovered that eIF3d/e forms a module that functions in translational elongation, co-translational quality control and subcellular targeting of membrane proteins that is critical for tumor growth. More recently, we defined the eIF3k/l module as a rheostat of ribosome content to secure spare translational capacity that can be mobilized during stress.

讲座联系人/Contact:

科技合作部 sci-tech02@westlake.edu.cn