时间：4月19日星期五10:00-11:30

Time：10:00-11:30 AM，Friday, April 19，2024

主持人：西湖大学生命科学讲席教授 于洪涛

    Host：Dr. Hongtao Yu, Chair Professor of School of Life Sciences

    地点：云栖校区3号楼312会议室

    Venue：Room 312, Building 3, Yunqi Campus

主讲嘉宾/Speaker:

Dr. James Hurley, professor, Department of Molecular and Cell Biology, University of California, Berkeley

James ("Jim") Hurley is a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. He was born in Moscow (the city in Idaho, USA, not Russia), graduated in Physics from San Francisco State University, and obtained his Ph.D. in Biophysics from the University of California, San Francisco. He was a senior investigator in the intramural program of the National Institutes of Health from 1992-2013, and joined the faculty of the University of California, Berkeley in 2013. He has been elected to the U.S. National Academy of Sciences, received the Hans Neurath award of the Protein Society, and has been a team leader in the Aligning Science Across Parkinson's Collaborative Research Network since 2020.

Dr. Hurley uses structural biology, biophysics, biochemistry, and cell biology approaches to understand the structure and function of cell membranes in health and disease. He is known for his work on the structure and mechanism of the ESCRT membrane scission machinery, coated vesicle and endosome biogenesis, lipid transporters and second messenger systems, and the autophagy core complexes.

讲座摘要/Abstract:

My lab studies the molecular machinery of sorting to lysosomes and signaling from them. Autophagy is the main mechanism cells use to degrade bulky cargoes such as organelles and aggregates. Autophagy is initiated by the ULK1 protein kinase complex and the class III PI 3-kinase complex I (PI3KC3-C1). The structure and activation of the ULK1-PI3KC3-C1 supercomplex will be described. Rab GTPases, including RAB7A, and their phosphorylation, appear to play multiple roles in autophagy and mitophagy. One such mechanism, involving a RAB7A phosphoregulatory switch and modulators of the PI 3-kinase complex II, will be described. I have had a long-standing interest in membrane scission by the ESCRTs. I will show an example of how ESCRTs act to seal autophagosomes, and another example of how ESCRTs defend cells from the spread of the tau protein in Alzheimer's disease by promoting lysosomal resilience.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn