时间：4月2日星期二16:00-17:30

Time：4:00-5:30 PM，Tuesday, April 2，2024

主持人：西湖大学生命科学学院讲席教授 裴端卿

    Host：Dr. Duanqing Pei, Chair Professor of School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus

主讲嘉宾/Speaker:

Dr. Kehkooi Kee, Tenured Professor, School of Medicine , Tsinghua University

Dr. Kee studied meiotic recombination during his graduate school at Weill Cornell Medical School in Prof Scott Keeney laboratory. After his PhD study, he joined Prof Renee Reijo Pera lab and became research associate at Stanford University in 2007. He became a principal investigator at School of Medicine, Tsinghua University since 2010 and he is now the tenured Professor in School of Basic Medical Sciences. His team is interested in understanding the molecular mechanisms underlying human germ cell development. Their current research projects include developing in vitro models of human germ cell development and studying mutations causing infertility manifested in clinical setting. They have built many in vitro differentiation and induction systems for studying human germ cells and their neighboring somatic cells, including spermatids, oocytes, and Sertoli cells. These in vitro systems also allow them to study the effect of microgravity on development of human germ cells in spacecraft.

讲座摘要/Abstract:

Studying molecular and cellular mechanisms of humna reproductive development have been hindered by limited samples and ethical constraints. Recently, multiomic studies at single-cell level and in vitro differentiation of stem cells into human germ cells have alleviated and empowered scientists to elucidate many interesting developmental mechanisms of human germ cell. We have combined these tools with animal models and clinical samples to study developmental programs of mouse and human oocytes  and spermatogonia stem cells (SSCs). We have identified secreting factors important for oocyte maturation and discovered a key transcription factor essential for SSCs development.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn