时间：7月27日星期二10:00-11:30    

Time：10:00-11:30 AM，Tues., July 27，2021

地点：西湖大学云栖校区5号楼学术报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus

主持人：西湖大学生命科学学院教授 于洪涛

Host：Prof. Hongtao Yu, School of Life Sciences

主讲嘉宾/Speaker:

Dr. Maofu Liao

Associate Professor of Cell Biology, Harvard Medical School

Dr.

Maofu Liao, Ph.D., is an Associate Professor of Cell Biology at Harvard Medical School. He received his Ph.D. from Albert Einstein College of Medicine in 2006, performed postdoctoral research at University of California, San Francisco, and joined the faculty in the Department of Cell Biology of Harvard Medical School in 2014.

讲座摘要/Abstract:

Present in all kingdoms of life, ATP-binding cassette (ABC) transporters form a large superfamily of integral membrane proteins. These proteins harness the energy of ATP binding and hydrolysis to translocate a multitude of chemically diverse substrates across cellular membranes. ABC transporters carry out their functions by undergoing cycles of large-scale conformational transition. Despite decades of studies and many available structures, the molecular mechanisms of most ABC transporters are still poorly defined. The ongoing revolution of cryo-EM has provided a unique opportunity for obtaining deep insights into these highly dynamic and versatile membrane protein machines. Through our cryo-EM studies of several ABC transporters that perform distinct functions, we have uncovered how distinct tasks of substrate translocation are accomplished by the unique actions of these transporters. Collectively, our findings demonstrate that ABC transporters have evolved to be highly efficient in ATP usage and work seamlessly with their designated substrates.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn