时间：6月7日星期一14:00-15:30    

Time：2:00-3:30 PM，Mon.，June 7，2021

地点：西湖大学云栖校区3号楼312会议室

Venue: Room 312, 3F, Building 3,  Yunqi Campus

主持人：西湖大学生命科学学院研究员 郭天南

Host：Dr. Tiannan Guo, School of Life Sciences

主讲嘉宾/Speaker:

Dr. Fan Liu

Professor for Structural Interactomics, Charité - Universitätsmedizin Berlin

Prof. Dr. Fan Liu graduated from Fudan University in Shanghai with a B.Sc. in Biology. Afterwards she joined the lab of Prof. Dr. Mike Goshe at North Carolina State University and obtained her PhD in Biochemistry in 2013. Fan did her postdoc in the lab of Prof. Dr. Albert Heck (Utrecht, The Netherlands).

In 2017 Fan joined the Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP) in Berlin as a group leader for Structural Interactomics and head of the proteomics research platform. In addition to her position at the FMP, Fan is jointly appointed as Professor for Structural Interactomics at Charité - Universitätsmedizin Berlin.

讲座摘要/Abstract:

Proteins are involved in almost all cellular processes. They are organized through extensive networks of interactions, regulating the working mechanisms of the cell with high fidelity and precision. However, characterization of the protein interactome has been an extremely challenging task due to the lack of highly confident and efficient technology. To address this issue, we describe a leap forward in cross-linking mass spectrometry demonstrating a new integrated workflow that robustly identifies thousands of protein-protein interactions (tens of thousands of cross-links) from (sub)proteome samples. We applied this novel XL-MS strategy to several highly complex samples, including the intact virion, the mitochondrion and the neuronal synapse. The XL-MS-based method not only reveals protein partnerships systematically but also provides critical insights into the architecture and spatial organization of the complex proteome in various biological systems.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn