时间：5月24日星期一16:00-17:30    

Time：4:00-5:30 PM，Mon.，May 24，2021

地点：西湖大学云栖校区3号楼312会议室

Venue: Room 312, 3F, Building 3,  Yunqi Campus

主持人：西湖大学生命科学学院研究员 谢琦 

Host：Dr. Qi Xie, School of Life Sciences

主讲嘉宾/Speaker:

Dr. Jianzhu Ma
Institute for Artificial Intelligence, Peking University  

Dr. Jianzhu Ma is an Associate Professor of Institute for AI at Peking University. Before joining Peking University, Dr. Ma is an assistant professor of Department of Computer Science and Department of Biochemistry at Purdue University. Dr. Ma is a computer scientist studying machine learning, focusing on challenges brought forward by data in science, medicine, and health. He has published extensively on applications to biomedicine (Nature Methods, Nature Cancer, Cell, Nature Communications, PNAS). His work received several best paper, talk, poster, and research awards from the top conferences such as RECOMB and ISMB. 

讲座摘要/Abstract:

Machine learning in biology faces a critical challenge: most of the models are still“black boxes” and difficult to interpret. Although accurate, they provide no meaningful insights about how their decisions are made and are insufficient in disease studies for which clinicians need to understand the mechanisms underlying the predictions. In this talk, I will describe how to build a new generation of interpretable deep learning frameworks by coupling the structure of the neural network with the internal workings of a cell. Such framework was able to 1) accurately predict combination therapies for leukemia patients, leading to the identification of promising new combinations; 2) suggest effective drug combinations in PDX tumors and significantly improve progression free survival compared to monotherapy.  

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn