时间：6月18日星期二16:00-17:30

Time：4:00-5:30 PM, Tuesday, June 18，2024

主持人：西湖大学生命科学学院特聘研究员 孙一

    Host：Dr. Yi Sun, Principal Investigator, School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus

主讲嘉宾/Speaker:

Dr. Xiaowei Chen, Professor, Chongqing Institute for Brain and Intelligence (CIBI)

Dr.Chen obtained his Bachelor's degree in Clinical Medicine and Master's degree in Neurobiology from the Third Military Medical University in 2004 and 2007, respectively. From 2008 to 2013, he obtained his Ph.D. degree in neuroscience from the Technical University of Munich in Germany and conducted postdoctoral research there. Since 2022, Dr. Chen has been the Director/Professor at the Chongqing Institute for Brain and Intelligence. Since 2020, he has also been a member of the Brain and Intelligence Advanced Innovation Center at the Chinese Academy of Sciences. Dr. Chen has made contributions to understanding the mechanisms underlying sensory information processing and memory and has published over 80 papers in scientific journals such as Nature, Science, Nature Neuroscience, Neuron, and PNAS. 

讲座摘要/Abstract:

We investigate cellular and circuit mechanisms underlying memory formation, consolidation, and persistence at multiple scales from synapses to single neurons to networks. At the cellular level, we identified a population of sparsely distributed neurons in the auditory cortex that exhibited a stable response pattern of high-frequency burst firing to the learned sounds. These cells are termed holistic bursting cells, which have been suggested to be the basis of the memory of the learned sounds in the auditory cortex. Moreover, we found that fear learning-induced a newly developed and nicotinic receptor-mediated signal in cortical astrocytes, which plays an important role in memory persistence. At the circuit level, we found that the medial entorhinal cortex layer II-dentate gyrus pathway exhibited a task-dependent persistent activity developed over spatial learning, and we identified the importance of the hypothalamic supramammillary nucleus-hippocampal CA2 pathway for social memory consolidation during rapid eye movement sleep. Therefore, we have partially dissected cellular and circuit mechanisms of memory formation, consolidation, and maintenance in the sensory cortex-entorhinal cortex-hippocampus-neocortex system.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn