时间：4月29日星期一16:00-17:30

Time：4:00-5:30 PM，Monday, April 29，2024

主持人：西湖大学生命科学讲席教授 于洪涛

    Host：Dr. Hongtao Yu, Chair Professor of School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus

主讲嘉宾1/Speaker1:

Dr. Volker Haucke, Professor, Department of Molecular Physiology and Cell Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

Dr. Volker Haucke studied biochemistry in Berlin (Germany) and Basel (Switzerland). Following his PhD that he received in 1997 from the University of Basel, he carried out postdoctoral research at Yale. He held appointments at the University of Göttingen and at the Freie Universität Berlin. Since 2012 he is Director at the Leibniz Forschungsinstitut für Molekulare Pharmacologie (FMP) and professor of molecular pharmacology at the Freie Universität Berlin and a member of the NeuroCure Cluster of Excellence. The overarching goal of his studies is to mechanistically understand how signaling lipids and their regulators control endocytic and endolysosomal membrane dynamics in neurons and in other cell types. Volker Haucke is a distinguished scientist whose contributions have been recognized by his election as a Member of Leopoldina, the German National Academy of Science, a Member of the Berlin-Brandenburg Academy of Science, the Avanti Award of the American Society for Biochemistry and Molecular Biology (ASBMB) 2017, and the Feldberg Prize for Research in Physiology and Pharmacology 2020. Since 2014 he is an elected member of the European Molecular Biology Organisation (EMBO). 

讲座摘要1/Abstract1:

In my talk I will discuss the localization, regulation, and molecular mechanism of action of PI kinases and phosphatases and their roles in endocytosis and within the endolysosomal system. Moreover, I will cover our recent advances in the analysis of the metabolic pathways that regulate the cellular synthesis and turnover of distinct PI phosphates at endosomes or lysosomes in response to altering nutrient conditions, discuss the mechanisms by which these lipids regulate endolysosomal membrane dynamics and metabolism, and provide examples of how dysregulation of these pathways may cause human disease. Our data provide a framework for how PI phosphate metabolism is integrated into the cellular network and identify PI kinases as targets for future therapeutics. 

主讲嘉宾2/Speaker2:

Dr. Fan Liu, Professor, Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

Fan graduated from Fudan University in Shanghai with a B.Sc. in Biology. Afterwards she joined the lab of Prof. Dr. Mike Goshe at North Carolina State University and obtained her PhD in Biochemistry in 2013. Fan did her postdoc in the lab of Prof. Dr. Albert Heck (Utrecht, The Netherlands).

 In 2017 Fan joined the Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP) in Berlin as a group leader for Structural Interactomics and head of the proteomics research platform. In addition to her position at the FMP, Fan is jointly appointed as Professor for Structural Interactomics at Charité - Universitätsmedizin Berlin. Fan has been awarded by many funding sources, including the most prestigious funding scheme STG-2020 from European Research Council,  Chan-Zuckerberg initiative, etc.

讲座摘要2/Abstract2:

Over the years, we’ve advanced cross-linking mass spectrometry by developing experimental methods and software tools and generated tens of thousands of PPIs from various biological systems, such as mitochondria, synapses, cells and virus particles. These data reveal numerous aspects of living systems - for example protein subcellular localizations, interactions, and architectures of suprabiomolecular machineries. Furthermore, these findings inform functional follow-up studies to further characterize the newly discovered protein structures, interactions, and spatially resolved networks, using approaches from structural biology, molecular biology, cell biology, neuroscience, and informatics.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn