时间：3月27日星期三10:00-11:30

Time：10:00-11:30 AM，Wednesday, March 27，2024

主持人：西湖大学生命科学特聘研究员 杨培国

    Host：Dr. Peiguo Yang, PI of School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus

主讲嘉宾/Speaker:

Dr. Junjun Ding, Professor of Sun Yat-Sen University

Dr. Junjun Ding is a full professor and doctoral advisor at Sun Yat-sen University. His research focuses primarily on several cutting-edge biomedical fields, including the epigenetic regulation of embryonic stem cells, somatic cell reprogramming and early embryonic development. Notably, he has leveraged iPS cells to establish tumor disease models. Dr. Ding’s contributions have been recognized through publication in renowned international journals, where he has authored or co-authored 12 papers as either the corresponding or first author, such as Nature, Cell Stem Cell (two papers), Cell Research (two papers), Genome Biology, Nature Structural & Molecular Biology, and Protein Cell. His groundbreaking work on chromatin architecture was even acknowledged as a key advancement by the journal of Nature Structural & Molecular Biology.

In 2016, Dr. Ding was selected for the Overseas High-Level Talents Program for Young Researchers, and in 2017, he became the leader of an innovative and entrepreneurial team under the Guangdong Province Pearl River Talent Program.

讲座摘要/Abstract:

Phase separation can regulate cell fate decisions. We found that the phase separation of transcription factors regulates TAD reorganization during somatic cell reprogramming, while the phase separation of structural regulatory factors regulates A compartment interaction during stem cell pluripotency maintenance and differentiation. Somatic cell reprogramming was facilitated by manipulation of TAD reorganization, which was regulated by OCT4 phase separation. In terms of the maintenance and differentiation of pluripotency, unlike the typical loop extrusion model, the phase separation of structural regulatory factors regulates A compartment interaction. Collectively, these findings support a model of three-dimensional chromatin interactions organized by phase separation, demonstrate a way to control cell fate by manipulating phase separation.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn