新闻与活动 活动信息

生命科学专题学术讲座 | 吴皓:Inflammasomes at the crossroads between basic science and therapeutic intervention

时间

2023年3月21日星期二
9:00-10:30

地点

线上会议

主持

西湖大学生命科学学院特聘研究员 马丹

受众

全体师生

分类

学术与研究

生命科学专题学术讲座 | 吴皓:Inflammasomes at the crossroads between basic science and therapeutic intervention

    时间:2023年3月21星期二9:00-10:30

Time:9:00-10:30 AM,Tuesday, Mar. 21st,2023

主持人:西湖大学生命科学学院特聘研究员 马丹

    Host:Dr. Dan Ma, PI of School of Life Sciences


主讲嘉宾/Speaker:

Dr. Hao Wu, Asa and Patricia Springer Professor of Structural Biology at Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Hao Wu, PhD, is the Asa and Patricia Springer Professor of Structural Biology at Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and a member of the National Academy of Sciences and the American Academy of Arts and Sciences. The Wu laboratory of mechanistic immunology focuses on elucidating cellular and structural regulation in innate immune pathways, in particular the inflammasome pathway. Activation of inflammasomes, IL-1 and IL-18 signaling, and pyroptotic cell death plays an important role in host defense against infection and cancer, whereas excessive inflammation driven by inflammasomes and the cytokine signaling pathways is causal or associated with many inflammation-driven diseases such as cardiovascular conditions and neurodegeneration. Her critical research provides new opportunities for drug targeting by therapeutic intervention of supramolecular complexes in cellular innate immunity. Among other biophysical methods, the Wu lab utilizes: 1) cryo-EM to provide a detailed understanding of molecular complexes which includes a large number of membrane proteins, 2) drug screening and validation of potential therapeutics in immune diseases and cancers, and 3) cellular imaging and other tools to delineate the assembly of supramolecular complexes in cells. She serves on the editorial board of Science and Cell, and her work has been recognized by a number of honors including the William B. Coley Award for Distinguished Research in Basic and Cancer Immunology, Cancer Research Institute in 2022 and AAI-Thermo Fisher Meritorious Career Award, American Association of Immunologists in 2023.


讲座摘要/Abstract:

In this talk, I will present our work on inflammasomes including the NLRP3 inflammasome and GSDMD


联系人/Contact:

生命科学学院

于文越 yuwenyue@westlake.edu.cn