个人简介

　　裘云庆教授现任西湖大学医学院副院长、博士生导师。1990年浙江大学硕士研究生毕业，曾任浙大一院常务副院长、终身教授，浙江大学求是特聘医师，现任国家传染病医学中心常务副主任、浙江省药物临床研究及评价重点实验室主任，享受国务院特殊津贴专家。2025年6月加入西湖大学医学院。

学术成果

　　主持国家“十二五”、“十三五”新药创制国家科技重大专项、国家863计划、国家自然科学基金、重大疑难疾病中西医临床协作项目、浙江省科技厅“尖兵计划”重大项目等国家级及省级重大课题15项。主持抗乙肝、流感、新冠病毒新药等临床试验20余项。在国内外发表论文200余篇，以第一负责人获浙江省科技进步奖一、二、三等奖等7项，申报和获批国家专利20余项。获2023年度全球高被引科学家（Highly Cited Researcher 2023）。

主要研究方向：

乙肝RNA干扰（RNAi）、反义RNA技术（ASO)、核衣壳蛋白装配抑制剂（CAM）和中药的抗乙肝病毒作用机制研究和临床试验。新冠、乙肝mRNA疫苗、新型免疫佐剂等免疫应答机制及免疫效果研究。抗乙肝病毒药物联合使用对乙肝功能性治愈研究。抗肝癌新靶点挖掘和抗肝癌新药研究。

代表论文

1. Yina Yu, Haoyang Hu, Yichun Zhang , Zhijuan Zhang, Shuaibing Ying, Shaohua Dong, Jinyao Dai, Yuqi Hong, Yunqing Qiu b, Yan Lou, Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation. Phytomedicine,143(2025): 156726.

2．Pan, Y; Dai, JY; Liu, Y; Wang, YJ; Zhang, QD; Lou, Y; Qiu, YQ, NAE1 protein: a prognostic, immunomodulatory, and therapeutic biomarker associated with neddylation in hepatocellular carcinoma, INT J BIOL MACROMOL, 23(2025):143539

3．Mengjia Lin; Xiaoyun Zheng; Jianing Yan; Fei Huang; Yilin Chen; Ran Ding; Jinka Wan; Lei Zhang; Chenliang Wang; Jinchang Pan; Xiaolei Cao; Kaiyi Fu; Yan Lou; Xin-Hua Feng; Junfang Ji; Bin Zhao; Fei Lan; Li Shen; Xianglei He; Yunqing Qiu; Jianping Jin. The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation. Nature Communications. 2024-06-11, (2024) 15:4995

4．Ying Zhou; Yintao Zhang; Fengcheng Li; Xichen Lian; Qi Zhu; Feng Zhu; Yunqing Qiu. Signature Identification for Spatial Proteomics. Journal of Molecular Biology, 2024, 435(14): 167944

5．Rongmeng Jiang, Bing Han, Wanhong Xu, Xiaoying Zhang, Chunxian Peng, Qiang Dang, Wei Sun, Ling Lin, Yuanlong Lin, Lingyan Fan, Dongqing Lv, Lei Shao, Ying Chen, Yunqing Qiu,  Xiao Xu, Hongzhou Lu. Olgotrelvir as a Single Agent Treatment of Nonhospitalized Patients with Covid-19,  NEJM Evid. 2024 Jun; 3(6): EVIDoa2400026.

6．Yingying Shi, Jiaxin Huang, Yu Liu, Jing Liu, Xuemeng Guo, Jianhua Li, Liming Gong, Xin Zhou, Guofeng Cheng, Yunqing Qiu*, Jian You*, Yan Lou*. Structural and biochemical characteristics of mRNA nanoparticles determine anti-SARS-CoV-2 humoral and cellular immune responses, Science Advances 2022, 8(47), eabo1827.

7．Yu Wei, Luo Qixia, Shen Ping, Chen Yunbo, Xu Hao, Xiao Yonghong, Qiu Yunqing. New options for bloodstream infections caused by colistin- or ceftazidime /avibactam-resistant Klebsiella pneumoniae. Int J Antimicrob Agents. 2021,58(6):106458.

8．Song Zhang, Kuerbannisha Amahong, Xiuna Sun, Xichen Lian, Jin Liu, Huaicheng Sun, Yan Lou, Feng Zhu and Yunqing Qiu, The miRNA: a small but powerful RNA for COVID-19, Briefings in Bioinformatics, 2021, 22(2): 1137-1149

9．Yan Lou #, Lin Liu #, Hangping Yao 1, Xingjiang Hu 1, Junwei Su 1, Kaijin Xu 1, Rui Luo 1, Xi Yang 1, Lingjuan He 1, Xiaoyang Lu 1, Qingwei Zhao 1, Tingbo Liang*, Yunqing Qiu *，Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial, Eur J Pharm Sci, 2020 Oct 25;105631

10．Wang L, Zhan YQ, Wu Z, Lin MJ, Jin XH, Jiang LS, Qiu YQ*. A novel multitarget kinase inhibitor BZG with potent anticancer activity in vitro and vivo enhances efficacy of sorafenib through PI3K pathways in hepatocellular carcinoma cells. Biomedicine & Pharmacotherapy. 2020;125: 110033.

联系方式

　　电子邮箱：qiuyunqing@westlake.edu.cn

　　实验室团队目前正在组建中，长期招收助理研究员、博士后、科研助理。欢迎感兴趣的有医学、药学、生物学和免疫学等相关学科背景的研究者和同学联系申请！