个人简介

1991-1996年 北京医科大学，医学士

1996-2002年 日本久留米大学，细胞生物学博士

2002-2006年 美国Mayo Clinic 博士后

2006-2015年 美国密歇根大学医学院内科系助理教授，副教授，正教授

2015-2020年 美国希望之城贝克曼研究所正教授

2020年起       西湖大学生命科学学院正教授

学术成果

俞晓春教授长期致力于DNA损伤修复机制和癌症发生发展的研究。众所周知细胞内基因组随时面临着来自体外和体内的各种损伤因素的挑战，如果 DNA 的损伤得不到及时修复，则会导致细胞的细胞周期紊乱、细胞凋亡、癌症发生等等恶性结果。因此，如何正确完成 DNA 的损伤修复并维持基因组的稳定性，对于细胞的存活进而防止肿瘤等重大疾病的发生起着至关重要的作用。因而，与此相关的分子机制研究是 DNA 损伤修复生物学的核心内容，对于肿瘤的诊断、抗肿瘤药物的设计等都具有重要的理论指导意义。其学术成果特别对家族性乳腺癌，卵巢癌，胰腺癌和白血病检测和治疗产生巨大的影响。曾获2006年美国卵巢癌研究协会独立研究员奖，2007年美国癌症研究协会 （AACR）Susan G. Komen乳腺癌学者奖，2008年美国癌症协会（ACS）学者奖，2014年白血病淋巴癌协会学者奖，2018年Tower癌症研究基金会学者奖，2019年胰腺癌联盟转化医学研究奖，2019年Taub癌症研究基金会白血病研究奖。

代表论文

1. Kim H, Chen J* and Yu X*. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responses. Science. 316: 1202-1205. (* co-corresponding authors)

2. Liu Z, Wu J, and Yu X. (2007) CCDC98 targets BRCA1 to DNA damage sites. Nature Structural and Molecular Biology. 14: 716-720.

3. Huen M, Grant R, Manke I, Minn K, Yu X*, Yaffe M* and Chen J*. (2007) The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway. Cell. 131: 901-914. (* co-corresponding authors)

4. Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B * and Yu X*. (2009) PALB2 links BRCA1 and BRCA2 in the DNA damage response. Current Biology. 19: 524-529. (* co-corresponding authors)

5. Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL and Yu X. (2010) RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell. 18: 371-384.

6. Zhang F and Yu X. (2011) WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription. Molecular Cell. 41: 384-397.

7. Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO and Yu X. (2011) Chfr and RNF8 synergistically regulate ATM activation. Nature Structural and Molecular Biology. 18: 761-768.

8. Chen Q, Chen Y, Bian C, Fujiki R and Yu X. (2013) TET2 promotes histone O-GlcNacylation during gene transcription. Nature. 493 :561-564.

9. Ma T, Chen Y, Zhang F, Yang C-Y, Wang S and Yu X. (2013) RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Molecular Cell. 49: 897-907.

10. Li M and Yu X. (2013) Function of BRCA1 in the DNA damage response is mediated by ADPribosylation. Cancer Cell. 23: 693-704.

11. Lu L, Korakavi G, Kuang H and Yu X. (2013) Distinct DNA damage responses on male meiotic sex Chromosomes. Nature Communications. (3015)

12. Li M, Lu L, Yang C, Wang S and Yu, X. (2013) The FHA and BRCT domains recognize ADPribosylation during DNA damage response. Genes & Development. 27: 1752-1768.

13. Liu C, Wu J, Paudyal SC, You Z and Yu X. (2013) CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Research. 41 (3): 1698-1710.

14. Chen Y, Chen Q, McEachin RC, Cavalcoli JD and Yu X. (2014) H2A.B facilitates transcription elongation at methylated CpG loci. Genome Research. 24: 570-579.

15. Zhang F, Chen Y, Li M and Yu X. (2014) The OB-fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response. Proceedings of the National Academy of Sciences. 111: 7278-7283.

16. Bian C and Yu X. (2014) PGC7 suppresses TET3 for protecting DNA methylation. Nucleic Acids Research. 42 (5): 2893-2905.

17. Zhang F, Shi J, Chen S-H, Bian C and Yu X. (2015) The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response. Nucleic Acids Research. 43 (22): 10782-10794.

18. Chen Q and Yu X. (2016) OGT restrains the expansion of DNA damage signaling. Nucleic Acids Research. 44 (19): 9266-9278.

19. Li M, Chen Q, Ma T, and Yu X. (2017) Targeting reactive nitrogen species suppresses hereditary pancreatic cancer Proceedings of the National Academy of Sciences 114: 7106-7111

20. Liu C, Vyas A, Kassab MA, Singh AK and Yu X. (2017) The role of poly ADP-ribosylation in the first wave of DNA damage response. Nucleic Acids Research. 45 (14): 8129-8141.

21. Wang J, Yuan Z, Cui Y, Xie R, Wang M, Ma Y, Yu X* and Liu X*. (2018) Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR. Nature Communications. 9: 2689. (* co-corresponding authors)

22. Chen Q, Kassab MA, Dantzer F and Yu X. (2018) PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage. Nature Communications. 9: 3233.

23. Yang G, Liu C, Chen S-H, Kassab MA, Hoff JD, Walter NG and Yu X. (2018) Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors. Nucleic Acids Research. 46 (7): 3446-3457.

24. Bian C, Zhang C, Vyas A, Chen S-H, Liu C, Luo T and Yu X. (2019) NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nature Communications. 10: 693.

25. Chen S-H and Yu X. (2019) Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Science Advances. 5: eaav4340.

26. Chen S-H and Yu X. (2019) Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation. Nucleic Acids Research. 47 (3): 1321-1334.

27. Singh AK, Zhao B, Wang X, Li H, Qin H, Wu X, Ma Y, Horne D and Yu X. (2020) Selective targeting of TET catalytic domain promotes somatic cell reprogramming. Proceedings of the National Academy of Sciences. 117: 3621-3626.

28. Singh AK and Yu X. (2020) Tissue-specific-carcinogens as soil to seed BRCA1/2-mutant hereditary cancers. Trends in Cancer. 6: 559-568.

29. Yang G, Chen Y, Wu J, Chen S-H, Liu X, Singh AK and Yu X. (2020) Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions. Nucleic Acids Research. 48 (6): 3001-3013.

30. Chen Q*, Bian C, Wang X, Liu X, Kassab MA, Yu Y and Yu X*. (2021) ADP-ribosylation of histone variant H2AX promotes base excision repair. The EMBO Journal. 40: e104542. (* co-corresponding authors)

31. Chen Q*, Ma K, Liu X, Chen S-H, Li P, Yu Y, Leung A and Yu X*. (2022) Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis. Cell Discovery. 8: 3. (* co-corresponding authors)

32. Ma K, Luo M, Xie G, Wang X, Li Q, Gao L, Yu H and Yu X. (2022) Ribosomal RNA regulates chromosome clustering during mitosis. Cell Discovery. 8: 51.

33. Gai X, Xin D, Wu D, Wang X, Chen L, Wang Y, Ma K, Li Q, Li P and Yu X. (2022) Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response. Cell Research. 32: 254-268.

联系方式

电子邮箱：yuxiaochun@westlake.edu.cn