个人简介

　　谢琦（1984-），博士，浙江台州人。2007年本科毕业于中国农业大学生物学院，同年进入中国科学院生物物理研究所，于2012年获得中科院理学博士学位。2013年初进入克里夫兰医学中心（Cleveland Clinic）从事博士后研究工作，师从国际肿瘤干细胞领域的先驱之一Jeremy Rich博士。2017年8月跟随导师Jeremy Rich博士转到加州大学圣地亚哥分校（University of California San Diego，UCSD），并晋升为助理项目科学家（Assistant Project Scientist）。谢琦博士于2019年9月全职加入西湖大学生命科学学院，担任研究员、助理教授（独立PI）一职，继续从事肿瘤干细胞以及脑肿瘤的靶向治疗相关研究。

学术成果

肿瘤干细胞（Cancer Stem Cell）是肿瘤组织中一群具有自我更新、快速增殖，多向分化潜能、能够启动和重建肿瘤组织表型能力的癌细胞。 肿瘤干细胞参与肿瘤的转移、复发，促进肿瘤血管新生， 耐受化疗和放疗以及逃避免疫细胞的监视。 靶向肿瘤干细胞的治疗策略将有可能给癌症的治疗带来新的希望。谢琦博士一直从事肿瘤干细胞以及干细胞和所在肿瘤微环境相互作用的相关研究，从表观遗传学，转录调控水平，翻译后修饰水平以及代谢水平对其进行了系统性研究， 取得了一系列的研究成果，研究成果以第一作者或通讯作者身份发表在Cell, Cancer Discovery, Immunity, Nature Neuroscience，Journal of Clinical Investigation等国际著名杂志上， 并多次应邀在干细胞领域顶级杂志Cell Stem Cell 上发表评述和综述文章。现为美国癌症研究会会员（AACR Member, since 2016）,并作为独立审稿人多次为Clinical Cancer Research, Neuro-Oncology, Cancer letter等专业内著名杂志审稿。

当前实验室的研究方向集中（但不限于）以下几方面：

1. 肿瘤干细胞的表观遗传以及代谢调控

2. 肿瘤干细胞和肿瘤微环境的相互作用

3. 肿瘤免疫疗法（CAR-T,CAR-NK等）的改进

代表论文

1.Xie, Q. *, Wu, T. *, Gimple,C.R. *, Li, Z, ., Prager,C.B., Wu, Q., Yang, Y., Wang, P., Wang, Y., Gorkin, U.D., et al.(2018). N6-methyladenine DNA Modification in Glioblastoma. Cell 2018.10.006 (Co-first author) Highlighted by Nature Reviews Cancer, Cancer Discovery, Science Translational of Medicine and Nature Chemical Biology

2.Xie, Q., Wu, Q., Horbinski, C.M., Flavahan, W.A., Yang, K., Zhou, W., Dombrowski, S.M., Huang, Z., Fang, X., Shi, Y., et al. (2015). Mitochondrial control by DRP1 in brain tumor initiating cells. Nature neuroscience 18:501-5

3.Gimple, R.C., Kidwell, R.L., Kim, L.J.Y., Sun, T., Gromovsky, A.D., Wu, Q., Wolf, M., Lv, D., Bhargava, S., Jiang, L… Xie, Q#., Rich JN# (2019). Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Cancer Discovery 9, 1248-1267 (Co-corresponding author)

4.Xie, Q., Wu, Q., Kim, L., Miller, T.E., Liau, B.B., Mack, S.C., Yang, K., Factor, D.C., Fang, X., Huang, Z., et al. (2016). RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. The Journal of clinical investigation 126, 2757-2772. Highlighted by JCI and Cancer Discovery

5.Tang, M*., Xie, Q*#., Gimple, R.C*., Zhong, Z., Tam, T., Tian, J., Kidwell, R.L., Wu, Q., Prager, B.C., Qiu, Z., et al. (2020). Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Reserch (Co-first and Co-corresponding author）

6.Prager, B. C. *, Xie, Q. *, Bao, S. D. & Rich, J. N. (2019) Cancer Stem Cells: The Architects of the Tumor Ecosystem. Cell Stem Cell 24, 41-53, (Co-first author)

7.Xie, Q., Flavahan W.A., Bao S., Rich J. (2014) The Tailless Root of Glioma: Cancer Stem Cells. Cell Stem Cell 15(2):114-6

8.Dongrui Wang, Briana C Prager, Ryan C Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu…Qi Xie#, Christine E Brown#, Jeremy N Rich#(2021). CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discovery 11,1192-1211(Co-corresponding author)

9.Qiao Lu*, Jia Liu*, Shuai Zhao*, Maria Florencia Gomez Castro, Maudry Laurent-Rolle, Jianbo Dong, Xiaojuan Ran, Payal Damani-Yokota, Hongzheng Tang, Triantafyllia Karakousi…Siyuan Ding#, Qi Xie#, Jun Wang#（2021）SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through ACE2-independent interactions via C-type lectin receptors and TTYH2. Immunity 54,1304-1319(Co-corresponding author)

10.Miller, T.E., Liau, B.B., Wallace, L.C., Morton, A.R., Xie, Q., Dixit, D., Factor, D.C., Kim, L.J.Y., Morrow, J.J., Wu, Q., et al. (2017). Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature 547:355-359

 11. Zhen Xia, Min Tang, Jiayan Ma, Hongyan Zhang, Ryan C Gimple, Briana C Prager, Hongzhen Tang…Qi Xie# (2021) Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase. Nucleic Acid Research 49,7361-7374

12. Zhilin Long, Chengfang Sun, Min Tang, Yin Wang, Jiayan Ma, Jichuan Yu, Jingchao Wei, Jianzhu Ma, Bohan Wang#, Qi Xie#, Jiaming Wen# (2022) Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma.Cell Discovery 8,1-21(Co-corresponding author)

联系方式

　　电子邮箱 ：xieqi@westlake.edu.cn

实验室网站：https://xieqi.lab.westlake.edu.cn/