个人简介

黄来源博士于2004年在澳大利亚悉尼加文医学研究所（Garvan Institute of Medical Research）完成系统的博士研究训练。在完成博士后研究工作后，于2009年加入新加坡科技局免疫研究院（Singapore Immunology Network, SIgN）并独立组建研究团队，由此开启了在髓系细胞生物学领域的深耕。历经十三载深耕，黄来源博士通过一系列开创性研究，系统揭示了髓系细胞的发育谱系、动态行为及组织微环境适应机制，成为该领域公认的资深专家。2023年，黄来源博士受聘为上海市免疫治疗研究院资深研究员，同时担任免疫系统中心主任及上海交通大学教授。其卓越的学术贡献体现在多篇发表于《Science》《Immunity》《Science Immunology》《Journal of Experimental Medicine》《Science Advances》《Advanced Materials》和《Nature Protocols》等顶级期刊的突破性研究成果中。此外，黄来源博士已连续五年（2020-2024）入选科睿唯安"全球高被引科学家"榜单，充分彰显了其学术研究的国际影响力。

学术成果及研究方向

黄来源博士实验室的主要研究方向是探索免疫细胞在完整器官中发挥功能的机制。通过结合活体成像模型、质谱流式细胞术、流式细胞分析、转录组学和生物信息学等多学科方法，团队致力于解析白细胞（包括中性粒细胞和单核细胞）的发育路径，以及调控白细胞稳态的细胞与分子事件级联反应。

代表论文

1.T. Vicanolo, A. Özcan, J. L. Li, C. Huerta-López, I. Ballesteros, A. Rubio-Ponce, A. C. Dumitru, J. Nicolás-Ávila, M. Molina-Moreno, P. Reyes-Gutierrez, A. D. Johnston, C. Martone, E. Greto, A. Quílez-Alvarez, E. Calvo, E. Bonzon-Kulichenko, R. Álvarez-Velez, M. Y. Chooi, I. Kwok, B. González-Bermúdez, B. Malleret, F. M. Espinosa, M. Zhang, Y. L. Wang, D. Sun, S. Zhen Chong, A. El-Armouche, K. K. Kim, I. A. Udalova, V. Greco, R. Garcia, J. Vázquez, A. Dopazo, G. R. Plaza, J. Alegre-Cebollada, S. Uderhardt#, L. G. Ng#, A. Hidalgo#, Matrix-producing neutrophils populate and shield the skin. Nature 641, 740 (May, 2025). (#Co-corresponding author).
2.M. Ng#, D. Cerezo-Wallis#, L. G. Ng#, A. Hidalgo#, Adaptations of neutrophils in cancer. Immunity 58, 40 (Jan 14, 2025). (#Co-corresponding author).
3.L. G. Ng#, I. Kwok#, Transcending life and death: The ultimate cargo of aged neutrophils. Cell 188, 1460 (Mar 20, 2025). (#Co-corresponding author).
4.L. Dong#, L. G. Ng#, Tumor neutrophils rewired from birth. Cancer cell (May 22, 2025). (#Last co-corresponding author).
5.M. S. F. Ng#, I. Kwok, L. Tan, C. Shi, D. Cerezo-Wallis, Y. Tan, K. Leong, G. F. Calvo, K. Yang, Y. Zhang, J. Jin, K. H. Liong, D. Wu, R. He, D. Liu, Y. C. Teh, C. Bleriot, N. Caronni, Z. Liu, K. Duan, V. Narang, I. Ballesteros, F. Moalli, M. Li, J. Chen, Y. Liu, L. Liu, J. Qi, Y. Liu, L. Jiang, B. Shen, H. Cheng, T. Cheng, V. Angeli, A. Sharma, Y. H. Loh, H. L. Tey, S. Z. Chong, M. Iannacone, R. Ostuni, A. Hidalgo, F. Ginhoux, L. G. Ng#, Deterministic reprogramming of neutrophils within tumors. Science 383, eadf6493 (Jan 12, 2024). (#Last co-corresponding author).
6.G. Li, Y. Sun, I. Kwok, L. Yang, W. Wen, P. Huang, M. Wu, J. Li, Z. Huang, Z. Liu, S. He, W. Peng, J. X. Bei, F. Ginhoux, L. G. Ng#, Y. Zhang#, Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish. Nature communications 15, 811 (Jan 27, 2024). (#Co-corresponding author).
7.G. Dunsmore, W. Guo, Z. Li, D. A. Bejarano, R. Pai, K. Yang, I. Kwok, L. Tan, M. Ng, C. De La Calle Fabregat, A. Yatim, A. Bougouin, K. Mulder, J. Thomas, J. Villar, M. Bied, B. Kloeckner, C. A. Dutertre, G. Gessain, S. Chakarov, Z. Liu, J. Y. Scoazec, A. M. Lennon-Dumenil, T. Marichal, C. Sautès-Fridman, W. H. Fridman, A. Sharma, B. Su, A. Schlitzer, L. G. Ng#, C. Blériot#, F. Ginhoux#, Timing and location dictate monocyte fate and their transition to tumor-associated macrophages. Science immunology 9, eadk3981 (Jul 26, 2024). (#Co-corresponding author).
8.B. Su, L. G. Ng, Immunological modulation in health and disease. Cellular & molecular immunology 20, 981 (Sep, 2023).
9.J. Qu, J. Jin, M. Zhang#, L. G. Ng#, Neutrophil diversity and plasticity: Implications for organ transplantation. Cellular & molecular immunology 20, 993 (Sep, 2023). (#Co-corresponding author).
10.L. G. Ng#, Z. Liu, I. Kwok#, F. Ginhoux#, Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils. Annual review of immunology 41, 375 (Apr 26, 2023). (#Co-corresponding author).
11.M. Li, M. Ng, L. G. Ng, Firing up neutrophil anti-tumor immunity with cocktails. Cancer cell 41, 227 (Feb 13, 2023).
12.Y. Zhang, Q. Wang, C. R. Mackay, L. G. Ng, I. Kwok, Neutrophil subsets and their differential roles in viral respiratory diseases. Journal of leukocyte biology 111, 1159 (Jun, 2022). (Corresponding author).
13.Y. C. Teh, M. Y. Chooi, D. Liu, I. Kwok, G. C. Lai, L. Ayub Ow Yong, M. Ng, J. L. Y. Li, Y. Tan, M. Evrard, L. Tan, K. H. Liong, K. Leong, C. C. Goh, A. Y. J. Chan, N. B. Shadan, C. K. Mantri, Y. Y. Hwang, H. Cheng, T. Cheng, W. Yu, H. L. Tey, A. Larbi, A. St John, V. Angeli, C. Ruedl, B. Lee, F. Ginhoux, S. L. Chen, L. G. Ng#, J. L. Ding#, S. Z. Chong#, Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Science advances 8, eabj4641 (Mar 4, 2022). (#Co-corresponding author).
14.Y. Tan, H. L. Tey, S. Z. Chong#, L. G. Ng#, Skinny deeping: Uncovering immune cell behavior and function through imaging techniques. Immunological reviews 306, 271 (Mar, 2022). (#Co-corresponding author).
15.M. S. F. Ng#, L. Tan, Q. Wang, C. R. Mackay, L. G. Ng#, Neutrophils in cancer-unresolved questions. Science China. Life sciences 64, 1829 (Nov, 2021). (#Co-corresponding author).
16.M. Evrard, I. Kwok, L. G. Ng, Intrafemoral Delivery of Hematopoietic Progenitors. Methods in molecular biology 2308, 151 (2021).
17.L. G. Ng, Immune imaging: Seeing the immune system in a new light. Cellular immunology 350, 104067 (Apr, 2020).
18.I. Kwok#, E. Becht, Y. Xia, M. Ng, Y. C. Teh, L. Tan, M. Evrard, J. L. Y. Li, H. T. N. Tran, Y. Tan, D. Liu, A. Mishra, K. H. Liong, K. Leong, Y. Zhang, A. Olsson, C. K. Mantri, P. Shyamsunder, Z. Liu, C. Piot, C. A. Dutertre, H. Cheng, S. Bari, N. Ang, S. K. Biswas, H. P. Koeffler, H. L. Tey, A. Larbi, I. H. Su, B. Lee, A. St John, J. K. Y. Chan, W. Y. K. Hwang, J. Chen, N. Salomonis, S. Z. Chong, H. L. Grimes, B. Liu, A. Hidalgo, E. W. Newell, T. Cheng, F. Ginhoux, L. G. Ng#, Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Immunity 53, 303 (Aug 18, 2020). (#Last co-corresponding author)
19.Z. Liu, Y. Gu, S. Chakarov, C. Bleriot, I. Kwok, X. Chen, A. Shin, W. Huang, R. J. Dress, C. A. Dutertre, A. Schlitzer, J. Chen, L. G. Ng, H. Wang, Z. Liu, B. Su, F. Ginhoux, Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell 178, 1509 (Sep 5, 2019).
20.M. Evrard#, I. W. H. Kwok, S. Z. Chong, K. W. W. Teng, E. Becht, J. Chen, J. L. Sieow, H. L. Penny, G. C. Ching, S. Devi, J. M. Adrover, J. L. Y. Li, K. H. Liong, L. Tan, Z. Poon, S. Foo, J. W. Chua, I. H. Su, K. Balabanian, F. Bachelerie, S. K. Biswas, A. Larbi, W. Y. K. Hwang, V. Madan, H. P. Koeffler, S. C. Wong, E. W. Newell, A. Hidalgo, F. Ginhoux, L. G. Ng#, Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity 48, 364 (Feb 20, 2018). (#Last co-corresponding author).

联系方式

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