个人简介

王怀民，2008年本科毕业于天津大学；2015年博士毕业于南开大学，随后在美国布兰迪斯大学化学系从事博士后研究。2019年9月加入西湖大学理学院任独立PI。

针对临床未满足的疾病治疗需求，课题组围绕生物材料和纳米医学的交叉前沿，开展了如下方向：多肽化学、体内原位构建功能材料、免疫治疗、纳米材料和纳米药物、生物膜靶向技术、神经生物学材料等。

学术成果

课题组利用化学、生物材料、生物学、药学、纳米医学和人工智能等多学科交叉优势，发展了基于多肽的生物医用材料，创制了多肽组装体和水凝胶等功能材料，为治疗型生物活性物质精准靶向递送和重大疾病的治疗奠定了基础。课题组目前主持多个国家和省市科研项目。共发表原创性论文100余篇，近5年,在国际著名SCI期刊以通讯作者发表多篇工作，包括 Nat. Mater., Nat. Commun.，Sci. Adv., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano， Adv. Mater.等。

    曾获得国家优秀青年科学基金，杭州521人才计划，“教育部学术新人奖”等多种荣誉。

实验室目前研究方向：

1）多肽生物材料和纳米医学

2）体内原位构建功能组装体系

3）肺部特异性靶向和跨黏膜递送

4）生物功能导向的自组装多肽AI预测和从头设计

近期代表论文

[1] Huayang Liu, Zilin Song, Yu Zhang, Bihan Wu, Dinghao Chen, Ziao Zhou, Hongyue Zhang, Sangshuang Li, Xinping Feng, Jing Huang,* and Huaimin Wang*, De novo design of self-assembling peptides with antimicrobial activity guided by deep learning. Nature Materials., 2025, 1-12

[2] Ying Li, Tengyan Xu, Yaoting Li, and Huaimin Wang*, Enzyme Induced Solid-like Condensates Formation of Engineered Peptide in Living Cells for Prostate Cancer Inhibition. Angewandte Chemie International Edition, 2025, e202504958

[3] Laicheng Zhou, Longchen Zhu, Cong Wang, Tengyan Xu, Jing Wang, Bin Zhang*, Xin Zhang* and Huaimin Wang*, Multiphasic condensates formed with monocomponent of tetrapeptides via phase separation. Nature Communications, 2025, 16, 2706

[4] Yu Fang, Junhui Shi, Juan Liang, Dan Ma*, Huaimin Wang*, Water-regulated viscosity-plasticity phase transitions in a peptide self-assembled muscle-like hydrogel. Nature Communications, 2025, 16, 1058.

[5]  Yaoting Li, Huanfei Lu, Liheng Lu, and Huaimin Wang*, Engineering Peptide Self-Assembly: Modulating Noncovalent Interactions for Biomedical Applications. Accounts of Materials Research,  2025, 6, 4, 447–461

[6]  Bihan Wu, Juan Liang, Xuejiao Yang, Yu Fang, Nan Kong, Dinghao Chen, and Huaimin Wang*, A programable peptidic hydrogel adjuvant for personalized immunotherapy in resected stage tumors, Journal of the American Chemical Society, 2024, 146, 12, 8585–8597

[7]  Dinghao Chen, Ziao Zhou, Nan Kong, Tengyan Xu, Juan Liang, Pingping Xu, Bingpeng Yao, Yu Zhang, Ying Sun, Ying Li, Bihan Wu, Xuejiao Yang, Huaimin Wang*, Inhalable SPRAY nanoparticles by modular peptide assemblies reverse alveolar inflammation in lethal Gram-negative bacteria infection. Science Advances, 2024, 10.37: eado1749.

[8] Bihan Wu, Xuejiao Yang, Nan Kong, Juan Liang, Sangshuang Li, and Huaimin Wang*, Engineering Modular Peptide Nanoparticles for Ferroptosis-Enhanced Tumor Immunotherapy. Angewandte Chemie International Edition, 2024, DOI: 10.1002/anie.202421703

[9] Ying Li, Liangbo Hu, Jing Wang, and Huaimin Wang*, Clustering of the Membrane Protein by Molecular Self-Assembly Downregulates the Signaling Pathway for Cancer Cell Inhibition. Nano Letters, 2024, 24, 34, 10681-10690.

[10] Chongyang Wu, Hongyue Zhang, Nan Kong, Bihan Wu, Xinhui Lin, and Huaimin Wang*, Dynamic Control of Cyclic Peptide Assembly to Form Higher-Order Assemblies. Angewandte Chemie International Edition, 2023, 135, 36, e202303455

[11] Tengyan Xu, Jiaqi Wang, Shuang Zhao, Dinghao Chen, Hongy Zhang, Yu Fang, Nan Kong, Ziao Zhou, Wenbin Li*, Huaimin Wang*, Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop. Nature Communications, 2023, 14,  3880

[12] Xuejiao Yang, Honglei Lu, Bihan Wu, and Huaimin Wang*, Triggered Self-Sorting of Peptides to Form Higher-Order Assemblies in Living System.  ACS Nano, 2022, 16, 11, 18244–18252

[13] Jing Wang, Liangbo Hu, Hongyue Zhang, Yu Fang, Tingliang Wang, and Huaimin Wang*, Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer. Advanced Materials. 2022, 34 (1), 2104704.

[14] Xuejiao Yang, Honglei Lu, Yinghua Tao, Laicheng Zhou, and Huaimin Wang*, Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid-Catalyzed Hydrolysis and Enzymatic Reactions. Angewandte Chemie International Edition, 2021, 60 (44), 23797-23804.

[15] Liangbo Hu, Ying Li, Xinhui Lin, Yucheng Huo, Hongyue Zhang and Huaimin Wang*, Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition. Angewandte Chemie International Edition,  2021, 60 (40), 21807-21816

更多请访问课题组网站：www.hm-wanglab.com

联系方式

wanghuaimin@westlake.edu.cn

课题组招生、招聘

本实验室目前招聘博士研究生、博士后、助理研究员及研究助理。欢迎对相关研究方向感兴趣，并且具有以下背景的学生加入我们！

a. 生物材料：生物医用材料、仿生材料、纳米医学、药学

b. 生物方向：化学生物学、免疫、神经生物学、医学、计算生物学、生物物理

c. 有机方向：高分子化学、药物化学、计算化学

d. 人工智能：对人工智能感兴趣的计算相关专业