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个人简介
徐和平，2014年于清华大学医学院免疫学研究所获得博士学位；2014-2019年先后在美国辛辛那提儿童医学研究中心以及哈佛-麻省理工Broad 研究所开展博士后研究工作。2019年初入职西湖大学任研究员，研究方向为系统免疫学与免疫生理学。实验室研究项目获得国家自然基金委杰出科学基金项目、联合基金重点项目、科技部重点研发计划首席青年科学家项目、国家海外高层次青年人才计划等项目支持。
学术成果
免疫细胞的正常活化与分化是维持机体健康，抵御感染、过敏和癌症等疾病的必要条件。徐和平博士在调节免疫细胞分化与功能的内在分子机制与外在组织微环境方向做出了多项原创性的成果。目前实验室的主要研究兴趣在于探究免疫细胞与组织微环境的互作机制与网络，重点关注脑膜、肠道等屏障组织中代谢以及神经系统信号对免疫稳态和炎症反应的调节作用，以期为实现具有组织器官特异性靶向的精准免疫治疗奠定基础。
代表性论文
(*co-first author; #corresponding author)
1. Xu, H., Li, X., Liu, D., Li, J., Zhang, X., Chen, X., Hou, S., Peng, L., Xu, C., Liu, W., Zhang, L. & Qi, H. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496, 523-527 (2013).
2. Liu, D.*, Xu, H.*, Shih, C., Wan, Z., Ma, X., Ma, W., Luo, D. & Qi, H. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature 517, 214-218 (2015).
3. Xu, H., Chaudhri, V.K., Wu, Z., Biliouris, K., Dienger-Stambaugh, K., Rochman, Y. & Singh, H. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nature Immunology 16, 1274-1281 (2015).
4. Xu, H.*#, Ding, J.*, Porter, C.B.M., Wallrapp, A., Tabaka, M., Ma, S., Fu, S., Guo, X., Riesenfeld, S.J., Su, C., Dionne, D., Nguyen, L.T., Lefkovith, A., Ashenberg, O., Burkett, P.R., Shi, H.N., Rozenblatt-Rosen, O., Graham, D.B., Kuchroo, V.K., Regev, A.# & Xavier, R.J.# Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide alpha-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity 51, 696-708 e699 (2019).
5. Chen, D.*, Wang, Y.*, Manakkat Vijay, G.K.*, Fu, S., Nash, C.W., Xu, D., He, D., Salomonis, N., Singh, H.# & Xu, H.# Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation. Nature Immunology 22, 904-913 (2021).
6. Wang, Y.*, Chen, D.*, Xu, D.*, Huang, C., Xing, R., He, D.# & Xu, H.# Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges. Immunity 54, 2784-2794 e2786 (2021).
7. Cao, Y.*, Li, Y.*, Wang, X., Liu, S., Zhang, Y., Liu, G., Ye, S., Zheng, Y., Zhao, J., Zhu, X., Chen, Y., Xu, H., Feng, D., Chen, D., Chen, L., Liu, W., Zhou, W., Zhang, Z., Zhou, P., Deng, K., Ye, L., Yu, Y., Yao, Z., Liu, Q., Xu, H.# & Zhou, J.# Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity. Immunity 56, 320-335 e329 (2023).
8. Li, Y., Liu, S., Zhou, K., Wang, Y., Chen, Y., Hu, W., Li, S., Li, H., Wang, Y., Wang, Q., He, D. & Xu, H. Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. Science 381, 1189-1196 (2023).
9. Zang, Y., Liu, S., Rao, Z., Wang, Y., Zhang, B., Li, H., Cao, Y., Zhou, J., Shen, Z., Duan, S., He, D. & Xu, H. Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine. Immunity (2023).
联系方式
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