一、个人简介

江晓闽，福建龙岩人，1995年生于福建漳州。2018年本科毕业于四川大学化学系，导师为袁立华教授。毕业后就读于美国芝加哥大学，师从Wenbin Lin教授，于2023年获得化学生物学博士学位。随后于美国芝加哥大学Ludwig Center for Metastasis Research开展肿瘤免疫学博士后研究，合作导师为Ralph R. Weichselbaum和Wenbin Lin教授。2025年7月加入西湖大学，担任助理教授、博士生导师，研究内容主要集中在开发新型纳米材料，以解决基因治疗和癌症免疫学等重大生物医学难题，并研究纳米医学中的药物作用机制。

二、学术成果

江晓闽博士专注于通过化学合成纳米材料，致力于提高药物在肿瘤部位的选择性积累，并开发新型医药手段以应对肿瘤药物递送的挑战。通过有机合成前药设计或无机配位药物的方法，将药物负载于纳米递送材料中，实现持续的肿瘤靶向和治疗。基于这些科学发现，江晓闽博士积极参与转化医学研究，成功开发了用于系统递送的新型候选药物，并已完成一期临床试验，预计将为多种晚期和转移性肿瘤提供新的治疗方案。其代表性学术成果包括：

1. 通过将易降解的免疫激动剂与无毒金属配位，成功开发出具有长效循环和肿瘤靶向性的纳米材料，并揭示了纳米医学在增强免疫激动剂抗肿瘤免疫效果中的新机制。

2. 研究了纳米配位聚合物材料在化疗药物递送中的机制，发现其与血液中的低密度脂蛋白相互作用，并依赖低密度脂蛋白受体发挥抗肿瘤效果。

3. 开发出具备药物修饰能力的纳米级金属有机框架材料体系，适用于肿瘤原位植入药物，延长药物在肿瘤部位的滞留时间，并增强其与放疗、化疗和免疫疗法的协同作用。

三、代表论文

1. Xiaomin Jiang, Wenbin Lin*. Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy. Angew. Chem. Int. Ed. 2025, 64, e202423280.

2. Wenyao Zhen#, Xiaomin Jiang#, En Li, Morten J. Lee, Taokun Luo, Tomas Germanas, Ralph R. Weichselbaum* Wenbin Lin*. Remodeling Replicative Immortal Tumors into an Immunogenic and Vulnerable Phenotype via Nanoscale Coordination Polymers Mediated Cell-Senescence. Biomaterials 2025, 322, 123355.

3. Wangqing Bian#, Xiaomin Jiang#, Jinhong Li, Langston Tillman, Chaoyu Wang, Wenyao Zhen, Ralph R Weichselbaum, Tobias Fromme*, Wenbin Lin*. Metal-Organic Layer Delivers 3-Bromopyruvate to Mitochondria for Metabolic Regulation and Cancer Radio-Immunotherapy. Chem. Sci. 2025, 16, 5234-5240.

4. Xin Ma#, Xiaomin Jiang#, Zitong Wang#, Yingjie Fan, Jinhong Li, Cathleen Chow, Chaoyu Wang, Chenghua Deng, Wenbin Lin*. Cationic Metal-Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy. Angew. Chem. Int. Ed. 2024, 64, e202419409.

5. Chaoyu Wang#, Jinhong Li#, Xiaomin Jiang#, Xin Ma, Wenyao Zhen, Langston Tillman, Ralph R Weichselbaum*, Wenbin Lin*. Bifunctional Metal‐Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy. Angew. Chem. Int. Ed. 2024, 64, e202417027.

6. Xiaomin Jiang#, Taokun Luo#, Kaiting Yang, Morten J. Lee, Jing Liu, Langston Tillman, Wenyao Zhen, Ralph R. Weichselbaum, Wenbin Lin*. Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition for tumor eradication. Sci. Adv. 2024, 10, eado0082.

7. Taokun Luo#, Xiaomin Jiang#, Yingjie Fan, Eric Yuan, Jinhong Li, Langston Tillman, and Wenbin Lin*. STING Agonist-Conjugated Metal-Organic Framework Induces Artificial Leukocytoid Structures and Immune Hotspots for Systemic Antitumor Responses. Natl. Sci. Rev. 2024, 10, nwae167.

8. Taokun Luo#, Xiaomin Jiang#, Jinhong Li#, Geoffrey T. Nash, Eric Yuan, Luciana Albano, Langston Tillman, and Wenbin Lin*. Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy. Angew. Chem. Int. Ed. 2024, e202319981.

9. Jing Liu#, Xiaomin Jiang#, Youyou Li, Kaiting Yang, Ralph R. Weichselbaum* and Wenbin Lin*. Immunogenic Bifunctional Nanoparticle Suppresses PD-L1 Expression in Tumor and Dendritic Cells to Elicit Adaptive Immunity and Potent Chemo-Immunotherapy. ACS Nano 2024, 18, 6, 5152–5166.

10. Xiaomin Jiang#, Jing Liu#, Morten J. Lee, Cheng Peng, Taokun Luo,Langston Tillman, Ralph R. Weichselbaum, Wenbin Lin*. Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity. Biomaterials 2023, 302, 122334.

11. Xiaomin Jiang#, Morten J. Lee#, Taokun Luo, Langston Tillman, Wenbin Lin*. Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer. Biomaterials 2023, 301, 122235.

12. Xiaomin Jiang#, Jianqiao Liu#, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J. Lee, Wenbin Lin*. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis. Biomaterials 2023, 295, 122037.

13. Jing Liu#, Xiaomin Jiang#, Jianming Mao, Xuanyu Feng, Morten J. Lee, Youyou Li, Junjie Xia, Ralph R. Weichselbaum*, Wenbin Lin*. A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy. Small Method 2023, 2201437.

14. Kaiting Yang#, Wenbo Han#, Xiaomin Jiang#, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Hua Liang, Jenny P.Y. Ting, Yang-Xin Fu, Wenbin Lin*, Ralph R. Weichselbaum*. Zinc-c-di-AMP Nanoparticles Target and Suppress Tumors via Endothelial STING Activation and Tumor Associated Macrophage Reinvigoration. Nat. Nanotech. 2022, 17, 1322-1331. (Highlighted by UChicago BSD News)

15. Xiaomin Jiang, Jianqiao Liu, Morten J. Lee, Junjie Xia, Taokun Luo, Megan Rodriguez, Wenbin Lin*. Two-stage Release of SN38 from a Core-shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade. ACS Nano 2022, 16, 21417–21430.

16. Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J. Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R. Weichselbaum, Wenbin Lin*. Tumor-Activatable Nanoparticles Target Low-Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy. Adv. Sci. 2022, 2201614. 

17. Yingying Li#, Xiaomin Jiang#, Taokun Luo, Junjie Xia, Morten J. Lee, Ralph Weichselbaum, Wenbin Lin*. TLR3 Agonist Nanoscale Coordination Polymer Synergizes with Immune Checkpoint Blockade for Immunotherapy of Cancer. Biomaterials 2022, 290, 121831.

18. Xiaomin Jiang, Chunbai He, Wenbin Lin*. Supramolecular Metal-based Nanoparticles for Drug Delivery and Cancer Therapy. Curr. Opin. in Chem. Biol., 2021, 61, 143-153.

19. Xiang Ling#, Wenbo Han#, Xiaomin Jiang#, Megan Rodriguez, Pingping Zhu, Tong Wu, Wenbin Lin*. Point-source Burst of Coordination Polymer Nanoparticles for Tri-modality Cancer Therapy. Biomaterials 2021, 270, 120690.

国际专利申请

1.    Wenbin Lin, Xiaomin Jiang, Wenbo Han, Xuanyu Feng. Nanoparticles Containing Multiple Cleavable Prodrugs for Cancer Therapy. PCT Pub. No.: WO2022/040635.

2.    Wenbin Lin, Ziwan Xu, Wenyao Zhen, Xiaomin Jiang. Nanoscale Metal-Organic Frameworks with X-ray triggerable prodrugs for combination radiotherapy, chemotherapy, and immunotherapy. PCT Pub. No.: WO/2025/010407.

四、联系方式

电子邮箱：jiangxiaomin@westlake.edu.cn

课题组拟长期开展合成化学、材料化学、化学生物学、肿瘤免疫学、基因工程等交叉学科的基础与应用研究，开展以下方向的深入研究：开发新型递送核酸大分子/多肽的纳米递送系统；纳米颗粒与细胞互作微环境界面机制探究，揭示药物递送微观原理；纳米药物体内机制探究，提出药物递送新应用场景。目前，课题组计划招收博士后、科研助理和访问学生，详情如下：

博士后：1）获得有机合成、材料合成、化学生物学、化学、药学、免疫学、生物信息学、基因组学、生物化学、分子生物学、细胞生物学或其它相关博士学位；2）有责任心、耐心，在国际主流刊物或预印刊物（preprint）以第一作者发表过第一/共一研究型论文；3）注重团队合作，有良好的沟通能力，年龄不超过35周岁；4）优先考虑具有以下任一研究背景的申请人：在有机合成，纳米材料合成与表征，肿瘤免疫学，基因编辑，RNA生物学和核酸化学，生物信息学，基因组学以及相关研究方向有丰富研究经验；有3年以上药物设计或者纳米医学相关的合成化学经验；熟练掌握高通量测序文库构建和测序结果的生物信息学分析；熟练掌握细胞培养、动物实验、肿瘤免疫学流式表征、基因克隆等技术。有意应聘者请发送个人简历（页数不限）、科研工作总结（1-2页）和2位推荐人信息。

科研助理：具有化学、化学生物学、药学、免疫学、细胞生物学、材料学或生物医学工程等相关专业背景的应届或往届本科生和硕士生。欢迎申请者发送个人简历（请包括个人学习、工作经历和掌握的实验技术）。

博士研究生：获得包括但不限于化学、药学、化学生物学、生物化学、生物技术、分子生物学、细胞生物学、生物信息学、基因组学、计算机科学以及其它相关专业的应届与往届本科生或硕士生。欢迎有责任心、好奇心和耐心的博士研究生入组进行科研训练。