时间：2022年12月7日（周三）16:00~17:30

Time：4:00-5:30 PM, Wednesday, Dec. 7, 2022

地点：云谷校区E10-222

      云栖校区1号楼215

Venue: E10-222, Yungu Campus

        Room 215, Building 1, Yunqi Campus

主持人：西湖大学生命科学学院特聘研究员 马丽佳

Host: Dr. Lijia Ma, PI of School of Life Sciences

主讲人/Speaker：

Guojie Zhang

Center of Evolutionary & Organismal Biology, Zhejiang University

Guojie Zhang a Chair Professor in Zhejiang University. He completed Bachelor's degree at Xiamen University and received his PhD degree at Kunming Institute of Zoology, the Chinese Academy of Sciences in 2010. He received a Marie-Curie International Fellowship (2012-2014) and started his tenure-track Assistant Professor position at the Department of Biology, University of Copenhagen in 2015. He was promoted to Associate Professor and then Full Professor in 2017 (at the age of 35). Guojie Zhang is also the Adjunct Professor at the Kunming Institute of Zoology of the Chinese Academy of Sciences. He established the Villum Centre for Biodiversity Genomics at the University of Copenhagen in 2020. Since 2022, he moved his lab to Zhejiang University and initiated a new research Centre for Evolutionary and Organismal Biology. The major research interests of his group are in biodiversity genomics and genome evolution, driven by fascination of the enormous phylogenetic diversity of organisms and their extraordinary variation in morphology, physiology, and behavior. Prof. Zhang’s research programs address fundamental questions about the origin of species, including human evolution, using interdisciplinary approaches. His works have revealed molecular mechanisms underlying speciation and adaptation for a broad spectrum of animal taxa. His group has established ants as model systems for interdisciplinary studies of social behaviour at the eco-evo-devo interface. He has been (co-) leading several international genomics consortia including the Bird 10K (b10k.genomics.cn), the Genome 10K (https://genome10k.soe.ucsc.edu/), the Global Ant Genomics Alliance (antgenomics.dk), the Ruminant Genome Project, and the Earth Biogenomic Program. The results of his research frequently appear in high profile journals such as Science, Nature, Nature series journals and PNAS, and have been highlighted by public media such as the New York Times, National Geographic, BBC, Danmarks Radio, and the New Scientist.

报告题目/Title:

Long-term Evolutionary Process and Principle in Shaping the Human Genomic Features and Functions

讲座摘要/Abstract:

Common ancestry and natural selection are the two main concepts of Darwin’s evolutionary theory. Under this evolutionary framework, each species inherited genetic components from the common ancestors but also accumulated its own unique set of genetic differences gradually over long time periods. In this presentation, I will show our two recent research programs developed under such framework working on understanding the genomic evolutionary patterns across vertebrates including human. Whole genome comparison efforts across species in the past decade have highlighted the deep ancient origin of many genes in our body and mutations of which often cause deleterious effects. By integrating fossil evidence and genomic data, our recent study revealed that many biological functions in our body that support us to survive in terrestrial environment have evolved far before the first vertebrate landing. We showed that genetic regulatory elements related to development of limbs and cardio-respiratory systems could be traced back since the emergency of common ancestors of all bony fishes. Despite the widespread of inter-species conservation signals in the genomes, species also evolved unique set of genomic components at different pace which is partially determined by the mutations accumulated in each generation. To understand why the species have evolved at different paces, we measured the germline mutation rates across 68 vertebrate species and inferred the interaction between the mutation rates and various life-history traits across species. We discover that species-level fecundity related traits are the main ecological factors that can explain the interspecific mutation rate variation, suggesting a long-term selection and trade-off between quality and quantity on reproduction, a same principle also applies on human population in explaining the relationship between child mortality and fertility.

讲座联系人/Contact:

科技合作部 sci-tech02@westlake.edu.cn