时间：2022年12月5日（周一） 13:30-15:00

Time: 13:30-15:00, Monday, December 5, 2022

地点：西湖大学云谷校区E10-205

Venue: Room E10-205, Yungu Campus

主持人: 西湖大学工学院 鞠峰博士

Host: Dr. Feng Ju, Assistant Professor, Westlake University

主讲嘉宾/Speaker：

Prof.  Lixin Zhang 张立新

生物工程学院

华东理工大学

主讲人简介/Biography:

Prof. Zhang is the Director of National Key Laboratory of Bioreactor Engineering at East China University of Science and Technology. His research interest mainly focuses on taxonomy-guided diversification of marine microbial natural product library: mining synergistic medicines through high throughput screening and increasing their production titers through synthetic biology strategy. The progress of his Avermectin project won The National Award for Excellence in Science and Technologies. As Chief Scientist, he led the project sponsored by The National Key Fundamental Research Program of China, and was awarded Distinguished Young Scholars by NSFC. He is now serving as Editor-in-Chief for Synthetic and Systems Biotechnology, Associate Editor-in-Chief for Applied Microbiology and Biotechnology and the SYNBIOCHEM External Advisory Board for the Manchester Institute of Biotechnology. Previously, he served as the President for the International Chemical Biology Society (ICBS), an Executive Board Member of International Committee on the Biology of Actinomycetes (ISBA) and Genetics of Industrial Microorganisms (GIM).

讲座摘要/Abstract:

Microbial strains are smart in homeostasis for survival through adaption to evolution, and consequently the production of desired products such as secondary metabolites with potentials as drugs can be achieved through coordinated expression of key genes and optimization of culture conditions. In addition to their pesticide activities, avermectins (AVMs) have been identified as potent antibiotic agents for a wide range of drug-resistant pathogens. To rewire the genetic circuitry controlling their yields, we explored how to balance the biological chassis with functional parts and optimize their dynamical process for overproduce AVMs by 5Ms strategy. The cellular triacylglycerol (TAG) pool enables more carbon flux to be redirected towards polyketide biosynthesis. AVMs are now exclusively made in China, and intelligences learned from their discovery and overproduction will help transform microbes into a true power-house of innovation.

讲座联系人/Contact:

工学院石怀玮

shihuaiwei@westlake.edu.cn