时间：12月6日星期二16:00-17:30

Time：4:00-5:30 PM，Tuesday, Dec. 6th，2022

主持人：西湖大学生命科学学院特聘研究员 雷凯

    Host：Dr. Kai Lei, PI of School of Life Sciences

    地点：云谷校区E10-222

    Venue：E10-222, Yungu Compus

主讲嘉宾/Speaker:

Dr. Pengxu Qian, School of Medicine Zhejiang University

Prof. Pengxu Qian got his bachelor degree in 2006, and his Ph.D degree in 2012 from University of Science and Technology of China (USTC). During his postdoctoral training in Prof. Linheng Li’s lab at Stowers Institute for Medical Research from 2012 to 2017, Dr. Qian was funded by the American Society of Hematology (ASH) Scholar Award. In Nov 2017, Dr. Qian started his lab as principal investigator in School of Medicine Zhejiang University, to study the roles and regulatory mechanisms of therapeutic hematopoietic stem cells including hematopoietic stem cells and CAR-T cells. He has undertaken projects such as National Natural Science Foundation of China and the National Key Research and Development Plan, and has been selected into the National Natural Science Foundation for Distinguished Young Scholars and Distinguished Young Scholars in Zhejiang Province. 

In the past five years, Prof. Qian’s team and collaborators have demonstrated that Graphdiyne oxide nanosheets is an efficient and specific drug candidate against DNMT3A-mutant AML cells (Nat Commun, 2022), elucidated the ex vivo expansion of human circulating HSCs in 3D culture system (Protein Cell, 2022), exemplified the differential regulatory mechanisms underlying CAT-T cell exhaustion (Leukemia, 2022; Adv Sci, 2022; J Hematol Oncol, 2021), illustrated the roles and mechanisms of m6A reader YTHDF2 in HSC expansion (Cell Research, 2018), and demonstrated the critical roles of a differentially methylated region (DMR) DERARE in normal hematopoiesis and leukemogenesis (Cell Stem Cell, 2018).

讲座摘要/Abstract:

Recent studies have emerged that RNA modifications modulate every aspect of RNA fate, including translation efficiency, alternative splicing, RNA stability and RNA translocation, which play critical roles in stem cells and multiple diseases. snoRNAs are abundant ncRNAs of 50-300 nt, which directly base pair to complementary regions of rRNA, introduce site-specific ribose methylations (2’-O-Me) or pseudouridine modifications, and function in ribosome biogenesis and translation. In this talk, we will discuss our recent findings of the pivotal roles of snoRNA mediated rRNA modification in SARS-CoV-2 replication, which provides fundamental basis for developing inhibitors and specific snoRNA ASOs as effective therapeutic candidates against COVID-19. We will also illustrate the roles of snoRNAs and rRNA modification in the regulation of ribosome translation and and maintenance of hematopoietic stem cell self-renewal. 

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn