西湖名师论坛第七十六期 | Duanqing PEI(裴端卿):Cell Fate Control at the Chromatin Level

来源:科技合作部 发布时间:2020-01-07 作者:科技合作部

时间2020110日(周五)上午10:00-11:00

Time10:00-11:00 AM, Friday, Jan 10, 2020

地点:西湖大学云栖校区5号楼一楼学术报告厅

VenueLecture Hall, 1F, Building 5, Yunqi Campus

主持人:西湖大学生命科学学院讲席教授 于洪涛

HostHongtao YU, Chair Professor of School of Life Sciences, Westlake University



主讲人/SpeakerDuanqing PEI(裴端卿), Professor of Stem Cell Biology and former Director General of Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences; Founding Executive Deputy Director of Guangzhou Regenerative Medicine and Health Guangdong laboratory.

 

Dr. Pei received his PhD from the University of Pennsylvania in 1991 and completed his Postdoc training at the University of Michigan Medical Center and held academic appointments at University of Minnesota, Tsinghua University before joining Chinese Academy of Sciences in 2004. As Director General at GIBH between 2008-2018, he has made original discoveries concerning the cellular and molecular mechanisms of cellular reprogramming and cell fate control. Notably, he and his colleagues has uncovered vitamin C as a powerful epigenetic regulator that activates both DNA and Histone demethylases during reprogramming. His team also discovered that mesenchymal to epithelial transition or MET initiates cellular reprogramming which also led to new methods to generate human iPSCs and NPCs for therapeutic development. Most recently, his team discovered cJUN as a guardian of somatic cell fate and developed a new reprogramming method based on this concept. These findings laid the basic building blocks for a better understanding of cell fate control and provided some of the tools critical for regenerative medicine.


报告题目/Title:

Cell Fate Control at the Chromatin Level


讲座摘要/Abstract:

Cell-fate decisions remain poorly understood at the chromatin level. Using reprogramming as a model system, we have investigated chromatin accessibility dynamics during the conversion of MEFs to iPSCs induced by the classic Yamanaka factors, chemicals/growth factors, and a newly established non-Yamanaka factor system. In general, we can infer from that datasets accumulated so far that cell fate is controlled in a binary fashion as far as the chromatin state is concerned. Specifically, one can generalize that the conversion from MEFs to iPSCs entails closing and opening of chromatin loci. This ℅ logic appears to be true for all three modes of reprogramming. We further infer that this binary logic may be true for other cell fate control cases in vivo. However, these three methods differ in the dynamics in terms of timing and specificity. Future work is directed towards a universal understanding of cell fate control which may guide us towards more precise and efficient methods. Related topics may be presented.


讲座联系人/Contact:

科技合作部 毕老师

biguanying@westlake.edu.cn



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