西湖名师论坛第六十七期 | Yiqin Gao: From Dinucleotide to Chromatin, a Domain Segregation Perspective for Chromatin Structure Change in Development, Differentiation, Senescence and Certain Diseases

来源:科技合作部 发布时间:2019-11-18 作者:科技合作部

时间20191125日(周一)上午9:30-11:00

Time9:30-11:00 AM, Monday, Nov 25, 2019

地点:西湖大学云栖校区5号楼一楼学术报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus

主持人:西湖大学徐益明讲席教授,理学院执行院长 邓力

Host: Li Deng, XU Yiming Endowed Chair Professor, Executive Dean of School of Science, Westlake University



主讲人/SpeakerYiqin Gao, PhD, Professor, College of Chemistry and Molecular Engineering, Peking University; Senior PI, Biomedical Pioneering Innovation Center, Peking University


Professor Yiqin Gao received B.S. degree from Sichuan University (1993), M.S. degree from the Institute of Chemistry, Chinese Academy of Sciences (1996), and Ph.D. degree from the California Institute of Technology (2001, with Prof. Rudolph A. Marcus). After Postdoctoral Fellowship at CalTech (2001-2002, with Prof. Marcus) and Harvard University (2002-2004, with Prof. Martin Karplus), he joined Texas A&M University as Assistant Professor in Chemistry in 2005. Since 2009, He has been professor in the College of Chemistry and Molecular Engineering, Peking University. Prof. Gao has received numerous prestigious honors and awards, including the Pople Medal, the CMOA Prize, the Searle Scholar, the Camille and Henry Dreyfus New Faculty Award, the Clauser Prize, etc. He now serves as Editorial Board Member of multiple peer-reviewed journals, such as the ACS Central Science, the Chemistry of Materials, the Journal of Chemical Physics, the Journal of Physical Chemistry, the Chemical Physics Letters, and the Interdisciplinary Sciences, etc.


报告题目/Title:

From Dinucleotide to Chromatin, a Domain Segregation Perspective for Chromatin Structure Change in Development, Differentiation, Senescence and Certain Diseases


讲座摘要/Abstract:

The high-order chromatin structure plays an important role in gene regulation. The mechanism, especially the sequence dependence for the formation of varied chromatin structures in different cell states remain to be elucidated. In this talk, we try to touch on three questions: (1) What is the sequence dependence and chemical structure basis in the formation of high order chromatin structure, such as compartments? (2) How does the chromatin structure reflect the biological function of different cellular states and tissue-specificity? (3) How does this sequence-dependent chromatin structure formation manifest in different species? Based on the sequence properties, we divided the genome into two sequentially, epigenetically, and transcriptionally distinct regions. These two megabase-sized domains were found to spatially segregate, and to different extents in different cell types. They show enhanced segregation from each other in development, differentiation, and senescence, meanwhile the multi-scale forest-prairie spatial intermingling is cell-type specific and increases in differentiation, helping to define cell identity. We propose that the phase separation of the 1D mosaic sequence in the 3-D space serves as a potential driving force, and together with cell type specific epigenetic marks and transcription factors, shapes the chromatin structure in different cell types. Specifically, based on the analysis of latest published Hi-C data of post-implantation stages, we present a consistent view of the chromatin structural change and the corresponding sequence dependence. Chromatin shows systematic and overall increase of spatial segregation during embryonic development, but with notable mixing occurring at two stages, ZGA and implantation. The segregation level change largely coincides with the change of genetic and epigenetic properties, leading to a possible mechanism of functional realization during implantation was proposed. We will also discuss the possible chromatin structure changes in carcinogenesis.


讲座联系人/Contact:

科技合作部 毕老师

biguanying@westlake.edu.cn


 

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