西湖名师论坛第五十八期 | David Craik: Discovery and Applications of Cyclotides in Medicine and Agriculture

来源:科技合作部 发布时间:2019-10-10 作者:科技合作部

时间20191015日(周二)下午14:00-15:30

Time2:00-3:30 PM, Tuesday, Oct 15, 2019

地点:西湖大学云栖校区1号楼315

Venue: Room 315, Building 1, Yunqi Campus

主持人:西湖大学生命科学学院PI 党波波博士

Host: Dr. Bobo Dang, PI of School of Life Sciences, Westlake University



主讲人/SpeakerDr. David Craik, group leader and Professor of Chemistry at the Institute for Molecular Bioscience at The University of Queensland, Australia


David Craik obtained his PhD in organic chemistry from La Trobe University in Melbourne, Australia and undertook postdoctoral studies at Florida State and Syracuse Universities before taking up a lectureship at the Victorian College of Pharmacy in 1983. He was appointed Professor of Medicinal Chemistry and Head of School in 1988. He moved to University of Queensland in 1995 to set up a new biomolecular NMR laboratory and is currently an Australian Research Council Laureate Fellow. His research focuses on applications of cyclic peptides, toxins and NMR in drug design. He is a Fellow of the Australian Academy of Science and has received numerous national and international awards for his research, including the Ralph F. Hirschmann Award from the American Chemical Society and the GSK Award for Research Excellence. He is author of 690 papers and has trained 70 PhD students.


讲座摘要/Abstract:

Naturally occurring cyclic peptides offer great potential as leads for drug design. Our work focuses on a class of cyclic peptides known as cyclotides, which are topologically unique proteins in that they have a head-to-tail cyclised peptide backbone and a cystine knotted arrangement of disulfide bonds. This makes them exceptionally stable to chemical, thermal or enzymatic treatments and, indeed, they are amongst nature’s most stable proteins. They occur in plants from the Rubiaceae (coffee), Violaceae (violet), Solanaceae (potato), Fabaceae (Legume) and Cucurbitaceae (cucumber) families of plants. Their stability and compact structure make them an attractive protein framework onto which bioactive peptide epitopes can be grafted to stabilise them. More than two dozen examples have now been published where biologically active epitopes have been grafted onto cyclic peptide frameworks to produce lead molecules with potential in the treatment of cancer, cardiovascular disease, infectious disease, autoimmune disease (multiple sclerosis) and pain. In the past, solid-phase peptide chemistry has been the primary method used to make cyclotides for laboratory evaluations. This presentation will describe applications of grafted cyclotides in agriculture and medicine.


讲座联系人/Contact:

科技合作部 沈老师

shenxiaolian@westlake.edu.cn


 

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