程建军博士

Jianjun Cheng,Ph.D.

生物材料和药物递送实验室

联系

邮箱: chengjianjun@westlake.edu.cn

网站: https://www.cheng-lab.com/

程建军博士

Jianjun Cheng,Ph.D.

生物材料和药物递送实验室

联系

邮箱: chengjianjun@westlake.edu.cn

网站: https://www.cheng-lab.com/

个人简介


程建军教授,1993 年获天津南开大学化学学士学位,1996 年获美国南伊利诺伊大学化学硕士学位,2001 年获加州大学圣巴巴拉分校(University of California, Santa Barbara)材料科学博士学位。毕业后作为资深科学家在 Insert Therapeutics 工作至 2004 年,后在麻省理工学院从事博士后研究至 2005 年,同年就职伊利诺伊大学厄巴纳 - 香槟分校(University of Illinois at Urbana-Champaign)材料科学与工程系任助理教授,2011 年晋升为终身副教授,2015 年晋升为该系终身正教授并获得伊利诺伊大学杰出晋升教授奖,2016 年起任Hans Thurnauer 讲席教授。2021年8月起任西湖大学工学院院长和材料科学与工程讲席教授。



学术成果


程建军教授课题组共发表过文章 200余篇, 拥有已获批 40余项美国或国际专利。获得的荣誉包括美国国家自然科学基金会青年学者奖和美国国立卫生研究院院长创新奖,以及多次伊利诺伊大学优秀教学奖。研究领域包括高分子化学,多肽,纳米材料和纳米药物、药物输送、癌症靶向技术。


程建军教授是英国皇家化学会生物材料科学期刊的主编,同时也是中美纳米药物及生物纳米技术学会(CASNN)的共同创始人,执委(2015-至今)和主席(2019-2021)。他是美国国家发明家科学院院士(Fellow of National Academy of Inventors),美国科学促进会会士 (Fellow of American Association for the Advancement of Science), 美国医学与生物工程学院会士(Fellow of American Institute for Medical and Biological Engineering),美国化学会高分子化学会士(Fellow of ACS-POLY)。



代表论文(*代表通信作者)


1. Yang, Y., Ying, H., Li, Z., Wang, J., Ferguson, A., Zhang, Y., Cheng, J.* “Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent”, Nature Communications 2021, 12, 1572.

2. Xia, Y., Song, Z., Tan, Z., Xue, T. Wei, S., Zhu, L., Yang, Y., Fu, H., Jiang, Y., Lin, Y., Lu, Y., Ferguson, A.L., Cheng, J.* “Accelerated polymerizaton of N-carboxyanhydrides catalyzed by crown ether” Nature Communications 2021, 12, 372.

3. Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J.* “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574.

4. Song, Z.; Fu, H.; Baumgartner, R.; Zhu, L.; Shih, K.; Xia, Y.; Nieh, M., Chipot, C.; Lin, Y.; Cheng, J.* “Enzyme-mimetic, self-catalyzed polymerization of polypeptide helices”, Nature Communications, 2019, 10, 5470.

5. Song, Z.; Fu, H.; Wang, J.; Hui, J.; Xue, T.; Pacheco, L.A.; Yan, H.; Baumgartner, R.; Wang, Z.; Xia, Y.; Wang, X.; Yin, L.; Chen, C.; Rodríguez-Lópezd, J.; Ferguson, A.; Lin, Y.; Cheng, J.* “Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663

6. Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J.* “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides”, J. Am. Chem. Soc., 2019, 141, 8680-8693

7. Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.*; Cheng, J.*; Leong, K.W.* “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide”, PNAS, 2018, 115, 4903-4908

8. Lv, S. Wu, Y., Cai, K. He, H. Li, Y.; Lan, M.; Chen, X.; Cheng, J.*; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions” J. Am. Chem. Soc., 2018, 140, 1235–1238

9. Zhang, Y.; Cai, K.; Li, C.; Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.*; Jiang, C. “Macrophage Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908-1915

10. Song, Z., Fu, H.; Wang, R.; Pacheco, L.; Wang, X.; Lin, Y.; Cheng, J.* “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chemical Society Reviews, 2018, 47, 7401-7425.

11. Wang, H.; Wang, R.; Cai, K.; He H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.*; Yin, L.*; Cheng, J.* “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424.

12. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.*; Cheng, J.* “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622

13. Xiong M.; Bao Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song. Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. *“Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”. PNAS, 2017, 114, 12675-12680

14. Song, Z.; Mansbach, RA; He, H.; Shik, KC; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, MP; Ferguson, AL; Yin, L.; Cheng, J.* “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Communications., 2017, 8, 92

15. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”. Chemical Society Reviews, 2017, 46, 6570-6599

16. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J.* “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew Chem. Int. Ed., 2017, 56, 10826-10829

17. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.*; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106–11116

18. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J.* “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”, Angew Chem. Int. Ed. 2016, 55, 5452-5456



联系方式


电子邮箱:chengjianjun@westlake.edu.cn


程建军教授课题组拟长期高分子化学,高分子材料,纳米药物, 药物递送等基础与应用基础研究,主要研究方向包括:(1)多肽类高分子生物医用材料的合成制备和应用,(2)纳米药物,(3)小分子,蛋白类和基因类药物递送,(4)细胞标记和肿瘤靶向, (5)自修复材料。现课题组诚聘上述研究方向的杰出人才作为Co-PI,同时招聘研究员、副研究员、助理研究员、技术工程师、科研助理以及行政助理,具体岗位职责和应聘条件参见以下招聘链接:

https://www.westlake.edu.cn/Careers/OpenPositions/PostDoctoral/202105/t20210528_10331.shtml

https://www.westlake.edu.cn/Careers/OpenPositions/research/202105/t20210528_10329.shtml